Resting-state EEG dynamics help explain differences in response control in ADHD: Insight into electrophysiological mechanisms and sex differences.

Resting-state EEG dynamics help explain differences in response control in ADHD: Insight into electrophysiological mechanisms and sex differences.

Blog Article

Reductions in response control (greater reaction time variability and commission error rate) are consistently observed in those diagnosed with attention-deficit/hyperactivity disorder (ADHD).Previous research suggests Greeting these reductions arise from a dysregulation of large-scale cortical networks.Here, we extended our understanding of this cortical-network/response-control pathway important to the neurobiology of ADHD.

First, we assessed how dynamic changes in three resting-state EEG network properties thought to be relevant to ADHD (phase-synchronization, modularity, oscillatory power) related with response control during a simple perceptual decision-making task in 112 children/adolescents (aged 8-16) with and without ADHD.Second, we tested whether these associations differed in males and females who were matched in age, ADHD-status and ADHD- subtype.We found that changes in oscillatory power (as opposed to phase-synchrony and modularity) are most related with response control, and that this relationship is stronger in ADHD compared to controls.

Specifically, a tendency to dwell in an electrophysiological state characterized by high alpha/beta power (8-12/13-30Hz) and low delta/theta power (1-3/4-7Hz) supported response control, particularly in those with ADHD.Time in this state might reflect an increased initiation of alpha-suppression mechanisms, recruited by those with ADHD to suppress processing unfavourable to response control.We also found marginally significant evidence that this relationship I-3-C 200 is stronger in males compared to females, suggesting a distinct etiology for response control in the female presentation of ADHD.